Increased Risk Of Major And Minor Bleeding During Antiplatelet Therapy.
Risk of bleeding for patients on antiplatelet analysis with either warfarin or a bloc of Plavix (clopidogrel) and aspirin is substantial, a supplementary study finds. Both therapies are prescribed for millions of Americans to preclude life-threatening blood clots, especially after a heart attack or stroke. But the Plavix-aspirin claque was thought to cause less bleeding than it actually does, the researchers say.
And "As with all drugs, these drugs come with risks; the most not joking is bleeding," said lead author Dr Nadine Shehab, from the US Centers for Disease Control and Prevention (CDC). While the imperil of bleeding from warfarin is well-known, the risks associated with dual psychotherapy were not well understood, she noted. "We found that the risk for hemorrhage was threefold higher for warfarin than for dual antiplatelet therapy," Shehab said. "We expected that because warfarin is prescribed much more oft-times than dual antiplatelet therapy".
However, when the researchers took the tot of prescriptions into account, the lacuna between warfarin and dual antiplatelet therapy shrank, Shehab said. "And this was worrisome," she added. For both regimens, the compute of hospital admissions because of bleeding was similar. And bleeding-related visits to crisis department visits were only 50 percent lower for those on dual antiplatelet therapy compared with warfarin, Shehab explained. "This isn't as big a imbalance as we had thought," she said.
For the study, published Monday in the Archives of Internal Medicine, Shehab's set used national databases to categorize emergency department visits for bleeding caused by either dual antiplatelet therapy or warfarin between 2006 and 2008. The investigators found 384 annual difficulty department visits for bleeding amid patients taking dual antiplatelet therapy and 2,926 annual visits for those taking warfarin.
Saturday 30 November 2013
Thursday 28 November 2013
Fatal Case Of Black Plague In The USA
Fatal Case Of Black Plague In The USA.
In 2009, a 60-year-old American lab researcher was mysteriously, and fatally, infected with the hateful harass while conducting experiments using a weakened, non-virulent harm of the microbe. Now, a follow-up investigation has confirmed that the researcher died because of a genetic predisposition that made him unprotected to the hazards of such bacterial contact. The experimental report appears to set aside fears that the strain of plague in question (known by its meticulous name as "Yersinia pestis") had unpredictably mutated into a more lethal one that might have circumvented standard research lab surveillance measures.
And "This was a very isolated incident," said study co-author Dr Karen Frank, administrator of clinical microbiology and immunology laboratories in the department of pathology at the University of Chicago Medical Center. "But the conspicuous point is that all levels of public health were mobilized to research this case as soon as it occurred. "And what we now know," Frank added, "is that, despite concerns that we might have had a non-virulent burden of virus that unexpectedly modified and became virulent, that is not what happened.
This was an instance of a person with a peculiar genetic condition that caused him to be particularly susceptible to infection. And what that means is that the precautions that are typically charmed for handling this type of a-virulent strain in a lab setting are safe and sufficient". Frank and her UC colleague, Dr Olaf Schneewind, reported on the protection in the June 30 issue of the New England Journal of Medicine.
According to the National Institutes of Health, prairie dogs, rats and other rodents, and the fleas that mouthful them, are the postulate carriers of the bacteria responsible for the spread of the deadly plague, and they can infect kin through bites. In the 1300s, the so-called "Black Death" claimed the lives of more than 30 million Europeans (about one-third of the continent's amount population at the time). In the 1800s, 12 million Chinese died from the illness.
Today, only 10 to 20 Americans are infected yearly. As beforehand reported by the US Centers for Disease Control and Prevention on Feb 25, 2011, the circumstance of the American lab researcher began in September 2009, when he sought trouble oneself at a facility emergency room following several days of breathing difficulties, dry coughing, fevers, chills, and weakness. Thirteen hours after admission, he was dead.
In 2009, a 60-year-old American lab researcher was mysteriously, and fatally, infected with the hateful harass while conducting experiments using a weakened, non-virulent harm of the microbe. Now, a follow-up investigation has confirmed that the researcher died because of a genetic predisposition that made him unprotected to the hazards of such bacterial contact. The experimental report appears to set aside fears that the strain of plague in question (known by its meticulous name as "Yersinia pestis") had unpredictably mutated into a more lethal one that might have circumvented standard research lab surveillance measures.
And "This was a very isolated incident," said study co-author Dr Karen Frank, administrator of clinical microbiology and immunology laboratories in the department of pathology at the University of Chicago Medical Center. "But the conspicuous point is that all levels of public health were mobilized to research this case as soon as it occurred. "And what we now know," Frank added, "is that, despite concerns that we might have had a non-virulent burden of virus that unexpectedly modified and became virulent, that is not what happened.
This was an instance of a person with a peculiar genetic condition that caused him to be particularly susceptible to infection. And what that means is that the precautions that are typically charmed for handling this type of a-virulent strain in a lab setting are safe and sufficient". Frank and her UC colleague, Dr Olaf Schneewind, reported on the protection in the June 30 issue of the New England Journal of Medicine.
According to the National Institutes of Health, prairie dogs, rats and other rodents, and the fleas that mouthful them, are the postulate carriers of the bacteria responsible for the spread of the deadly plague, and they can infect kin through bites. In the 1300s, the so-called "Black Death" claimed the lives of more than 30 million Europeans (about one-third of the continent's amount population at the time). In the 1800s, 12 million Chinese died from the illness.
Today, only 10 to 20 Americans are infected yearly. As beforehand reported by the US Centers for Disease Control and Prevention on Feb 25, 2011, the circumstance of the American lab researcher began in September 2009, when he sought trouble oneself at a facility emergency room following several days of breathing difficulties, dry coughing, fevers, chills, and weakness. Thirteen hours after admission, he was dead.
Wednesday 27 November 2013
Pain Is A Harbinger Of The Last Months Of Life At Half The Elderly
Pain Is A Harbinger Of The Last Months Of Life At Half The Elderly.
Pain is a commonly reported cue during the up to date few years of life, with reports of misery increasing during the final few months, a new study has shown. Just over a fourth of consumers reported being "troubled" by moderate or severe pain two years before they died, the researchers found. At four months before death, that bevy had jumped to nearly half. "This swatting shows that there's a substantial burden of pain at the end of life, and not just the very end of life," said the study's cue author, Dr Alexander K Smith, an assistant professor of prescription at the University of California, San Francisco, and a staff physician at the San Francisco VA Medical Center.
And "Arthritis was the unattached biggest predictor of pain," Smith said. Results of the go into are published in the Nov 2, 2010 issue of the Annals of Internal Medicine. Smith and his co-authors penetrating out that numerous studies have been done on pain associated with specific conditions, such as cancer, but that theirs may be the prime to address pain from all conditions toward the end of life, a time when most people would say that being pain-free is a priority.
The scrutiny included information on more than 4700 people who died while participating in a study of older adults called the Health and Retirement Study. The bookwork participants averaged 76 years old, included marginally more men than women and were mostly (83 percent) white. Every two years, they were asked if they were troubled by pain. If they answered yes, they were asked to speed their pain as mild, soften or severe.
Pain is a commonly reported cue during the up to date few years of life, with reports of misery increasing during the final few months, a new study has shown. Just over a fourth of consumers reported being "troubled" by moderate or severe pain two years before they died, the researchers found. At four months before death, that bevy had jumped to nearly half. "This swatting shows that there's a substantial burden of pain at the end of life, and not just the very end of life," said the study's cue author, Dr Alexander K Smith, an assistant professor of prescription at the University of California, San Francisco, and a staff physician at the San Francisco VA Medical Center.
And "Arthritis was the unattached biggest predictor of pain," Smith said. Results of the go into are published in the Nov 2, 2010 issue of the Annals of Internal Medicine. Smith and his co-authors penetrating out that numerous studies have been done on pain associated with specific conditions, such as cancer, but that theirs may be the prime to address pain from all conditions toward the end of life, a time when most people would say that being pain-free is a priority.
The scrutiny included information on more than 4700 people who died while participating in a study of older adults called the Health and Retirement Study. The bookwork participants averaged 76 years old, included marginally more men than women and were mostly (83 percent) white. Every two years, they were asked if they were troubled by pain. If they answered yes, they were asked to speed their pain as mild, soften or severe.
Monday 25 November 2013
The Amount Of Caffeine Is Not Specified In Dietary Supplements For The Military
The Amount Of Caffeine Is Not Specified In Dietary Supplements For The Military.
A recent review finds that popular epilogue pills and powders found for sale at many military bases, including those that claim to boost energy and domination weight, often fail to properly describe their caffeine levels. Some of these products - also sold at health-food stores across the county - didn't stipulate any information about caffeine on their labels undeterred by being packed with it, and others had more or much less caffeine than their labels indicated. "Fewer than half of the supplements had for detail and useful information about caffeine on the label," said study lead author Dr Pieter Cohen, aid professor of medicine at Harvard Medical School. "If you're looking for these products to aide boost your performance, some aren't going to work and you're successful to be disappointed. And some have much more caffeine than on the label".
Researchers launched the study, funded by the US Department of Defense, to sum to existing knowledge about how much caffeine is being consumed by members of the military. Athletes and members of the military, they said, pretence a risk of health problems when they consume too much caffeine and exercise in the heat. Cohen emphasized that the supplements were purchased in civilian stores: "Why is it that 25 percent of the products labels with caffeine had false facts at a mainstream supplement retailer"?
He also explained the specific military concern. "We already skilled in that troops are drinking a lot of coffee and using a lot of energy drinks and shots," Cohen said. "Forty-five percent of effective troops were using energy drinks on a daily basis while they were in Afghanistan and Iraq. We're talking about stocky amounts of caffeine consumed, and our question is: What's growing on on top of that?"
A recent review finds that popular epilogue pills and powders found for sale at many military bases, including those that claim to boost energy and domination weight, often fail to properly describe their caffeine levels. Some of these products - also sold at health-food stores across the county - didn't stipulate any information about caffeine on their labels undeterred by being packed with it, and others had more or much less caffeine than their labels indicated. "Fewer than half of the supplements had for detail and useful information about caffeine on the label," said study lead author Dr Pieter Cohen, aid professor of medicine at Harvard Medical School. "If you're looking for these products to aide boost your performance, some aren't going to work and you're successful to be disappointed. And some have much more caffeine than on the label".
Researchers launched the study, funded by the US Department of Defense, to sum to existing knowledge about how much caffeine is being consumed by members of the military. Athletes and members of the military, they said, pretence a risk of health problems when they consume too much caffeine and exercise in the heat. Cohen emphasized that the supplements were purchased in civilian stores: "Why is it that 25 percent of the products labels with caffeine had false facts at a mainstream supplement retailer"?
He also explained the specific military concern. "We already skilled in that troops are drinking a lot of coffee and using a lot of energy drinks and shots," Cohen said. "Forty-five percent of effective troops were using energy drinks on a daily basis while they were in Afghanistan and Iraq. We're talking about stocky amounts of caffeine consumed, and our question is: What's growing on on top of that?"
Saturday 23 November 2013
Prevention Of Cardiovascular Diseases By Dietary Supplements
Prevention Of Cardiovascular Diseases By Dietary Supplements.
Regular doses of the dietary appurtenance Coenzyme Q10 incision in half the death rate of patients agony from advanced heart failure, in a randomized double-blind trial in May 2013. Researchers also reported a significant reduce in the number of hospitalizations for heart failure patients being treated with Coenzyme Q10 (CoQ10). About 14 percent of patients fascinating the supplement suffered from a major cardiovascular effect that required hospital treatment, compared with 25 percent of patients receiving placebos.
In nitty-gritty failure, the heart becomes weak and can no longer pump enough oxygen- and nutrient-rich blood throughout the body. Patients often knowledge fatigue and breathing problems as the heart enlarges and pumps faster in an endeavour to meet the body's needs. The study is scheduled to be presented Saturday at the annual convention of the Heart Failure Association of the European Society of Cardiology, in Lisbon, Portugal.
And "CoQ10 is the prime medication to improve survival in chronic heart failure since ACE inhibitors and beta blockers more than a decade ago and should be added to pillar heart failure therapy," lead researcher Svend Aage Mortensen, a professor with the Heart Center at Copenhagen University Hospital, in Denmark, said in a sodality tidings release. While randomized clinical trails are considered the "gold standard" of studies, because this original study was presented at a medical meeting, the data and conclusions should be viewed as preliminary until published in a peer-reviewed journal.
American cardiologists greeted the reported findings with alert optimism. "This is a investigate that is very promising but requires replication in a second confirmatory trial," said Dr Gregg Fonarow, a professor of cardiology at the University of California, Los Angeles, and a spokesman for the American Heart Association. Fonarow respected that earlier, smaller trials with Coenzyme Q10 have produced muddled results.
And "Some studies have shown no effect, while other studies have shown some improvement, but not nearly the formidable effects displayed in this trial. Coenzyme Q10 occurs needless to say in the body. It functions as an electron carrier in cellular mitochondria (the cell's "powerhouse") to domestic convert food to energy. It also is a powerful antioxidant, and has become a sought-after over-the-counter dietary supplement.
Regular doses of the dietary appurtenance Coenzyme Q10 incision in half the death rate of patients agony from advanced heart failure, in a randomized double-blind trial in May 2013. Researchers also reported a significant reduce in the number of hospitalizations for heart failure patients being treated with Coenzyme Q10 (CoQ10). About 14 percent of patients fascinating the supplement suffered from a major cardiovascular effect that required hospital treatment, compared with 25 percent of patients receiving placebos.
In nitty-gritty failure, the heart becomes weak and can no longer pump enough oxygen- and nutrient-rich blood throughout the body. Patients often knowledge fatigue and breathing problems as the heart enlarges and pumps faster in an endeavour to meet the body's needs. The study is scheduled to be presented Saturday at the annual convention of the Heart Failure Association of the European Society of Cardiology, in Lisbon, Portugal.
And "CoQ10 is the prime medication to improve survival in chronic heart failure since ACE inhibitors and beta blockers more than a decade ago and should be added to pillar heart failure therapy," lead researcher Svend Aage Mortensen, a professor with the Heart Center at Copenhagen University Hospital, in Denmark, said in a sodality tidings release. While randomized clinical trails are considered the "gold standard" of studies, because this original study was presented at a medical meeting, the data and conclusions should be viewed as preliminary until published in a peer-reviewed journal.
American cardiologists greeted the reported findings with alert optimism. "This is a investigate that is very promising but requires replication in a second confirmatory trial," said Dr Gregg Fonarow, a professor of cardiology at the University of California, Los Angeles, and a spokesman for the American Heart Association. Fonarow respected that earlier, smaller trials with Coenzyme Q10 have produced muddled results.
And "Some studies have shown no effect, while other studies have shown some improvement, but not nearly the formidable effects displayed in this trial. Coenzyme Q10 occurs needless to say in the body. It functions as an electron carrier in cellular mitochondria (the cell's "powerhouse") to domestic convert food to energy. It also is a powerful antioxidant, and has become a sought-after over-the-counter dietary supplement.
Friday 22 November 2013
Allergic To Penicillin May Not Apply To Related Antibiotics
Allergic To Penicillin May Not Apply To Related Antibiotics.
Most patients who have a relation of penicillin allergy can safely effect antibiotics called cephalosporins, researchers say. Cephalosporins - which are coupled to penicillin in their structure, uses and effects - are the most over and over prescribed class of antibiotics.
So "Almost all patients undergoing major surgery pocket antibiotics to reduce the risk of infections. Many patients with a history of penicillin allergy don't get the cephalosporin because of a anxiety of possible drug reaction.
They might get a second-choice antibiotic that is not quite as effective," memorize author Dr James T Li, of the Mayo Clinic in Rochester, Minn, said in a announcement release from the American Academy of Allergy, Asthma & Immunology. He and his colleagues conducted penicillin allergy flay tests on 178 patients who reported a history of awful allergic (anaphylactic) reaction to penicillin.
Most patients who have a relation of penicillin allergy can safely effect antibiotics called cephalosporins, researchers say. Cephalosporins - which are coupled to penicillin in their structure, uses and effects - are the most over and over prescribed class of antibiotics.
So "Almost all patients undergoing major surgery pocket antibiotics to reduce the risk of infections. Many patients with a history of penicillin allergy don't get the cephalosporin because of a anxiety of possible drug reaction.
They might get a second-choice antibiotic that is not quite as effective," memorize author Dr James T Li, of the Mayo Clinic in Rochester, Minn, said in a announcement release from the American Academy of Allergy, Asthma & Immunology. He and his colleagues conducted penicillin allergy flay tests on 178 patients who reported a history of awful allergic (anaphylactic) reaction to penicillin.
Wednesday 20 November 2013
Glaucoma Is Attacking The US Population
Glaucoma Is Attacking The US Population.
The changing makeup of the US populace is expected to actress to an increase in cases of glaucoma, the leading cause of vision ruin in the country, experts say. A number of demographic and health trends have increased the numeral of Americans who fall into the major risk groups for glaucoma. These trends include: the aging of America, increase in the black and Hispanic populations, the ongoing obesity epidemic.
And as more people become at risk, steady eye exams become increasingly important, eye experts say. Early detection of glaucoma is leading to preserving a person's sight, but eye exams are the only way to catch the complaint before serious damage is done to vision. "The big thing about glaucoma is that it doesn't have any signs or symptoms," said Dr Mildred Olivier of the Midwest Glaucoma Center in Hoffman Estates, Ill, and a embark on fellow of Prevent Blindness America.
And "By the time someone says, 'Gosh, I have a problem,' they are in the end stages of glaucoma," Olivier said. "It's already captivated most of their sight away. That's why we title glaucoma 'the sneak thief of sight.'"
Glaucoma currently affects more than 4 million Americans, although only half have been diagnosed, according to the Glaucoma Research Foundation. It's cited as the cause of 9 to 12 percent of all cases of blindness in the United States, with about 120000 forebears blinded by the disease.
Glaucoma is most often caused by an broaden in the routine fluid pressure inside the eye, according to the US National Eye Institute. The added lean on damages the optic nerve, the bundle of more than a million nerve fibers that shoot signals from the eye to the brain. In most cases, people first notice that they have glaucoma when they begin to mislay their peripheral vision.
By then, it's too late to save much of their eyesight. "Glaucoma is the calculate one cause of irreversible but avoidable blindness," said Dr Louis B Cantor, chairman and professor of ophthalmology at the Indiana University School of Medicine and foreman of the glaucoma service at the Eugene and Marilyn Glick Eye Institute in Indianapolis. "By the fix it's noticeable, 70 to 90 percent of dream has been lost," he said. "Once it's gone, it's gone. There's no retrieving scheme lost to glaucoma".
The most common risk factor for glaucoma is simply surviving. "Glaucoma is a c murrain of aging," Cantor said. "The risk of developing glaucoma goes up considerably with aging". As the natives of the United States ages, the number of glaucoma cases will logically increase. As Olivier said, "We're just going to have more people who are older and living longer, so we'll have more glaucoma".
The changing makeup of the US populace is expected to actress to an increase in cases of glaucoma, the leading cause of vision ruin in the country, experts say. A number of demographic and health trends have increased the numeral of Americans who fall into the major risk groups for glaucoma. These trends include: the aging of America, increase in the black and Hispanic populations, the ongoing obesity epidemic.
And as more people become at risk, steady eye exams become increasingly important, eye experts say. Early detection of glaucoma is leading to preserving a person's sight, but eye exams are the only way to catch the complaint before serious damage is done to vision. "The big thing about glaucoma is that it doesn't have any signs or symptoms," said Dr Mildred Olivier of the Midwest Glaucoma Center in Hoffman Estates, Ill, and a embark on fellow of Prevent Blindness America.
And "By the time someone says, 'Gosh, I have a problem,' they are in the end stages of glaucoma," Olivier said. "It's already captivated most of their sight away. That's why we title glaucoma 'the sneak thief of sight.'"
Glaucoma currently affects more than 4 million Americans, although only half have been diagnosed, according to the Glaucoma Research Foundation. It's cited as the cause of 9 to 12 percent of all cases of blindness in the United States, with about 120000 forebears blinded by the disease.
Glaucoma is most often caused by an broaden in the routine fluid pressure inside the eye, according to the US National Eye Institute. The added lean on damages the optic nerve, the bundle of more than a million nerve fibers that shoot signals from the eye to the brain. In most cases, people first notice that they have glaucoma when they begin to mislay their peripheral vision.
By then, it's too late to save much of their eyesight. "Glaucoma is the calculate one cause of irreversible but avoidable blindness," said Dr Louis B Cantor, chairman and professor of ophthalmology at the Indiana University School of Medicine and foreman of the glaucoma service at the Eugene and Marilyn Glick Eye Institute in Indianapolis. "By the fix it's noticeable, 70 to 90 percent of dream has been lost," he said. "Once it's gone, it's gone. There's no retrieving scheme lost to glaucoma".
The most common risk factor for glaucoma is simply surviving. "Glaucoma is a c murrain of aging," Cantor said. "The risk of developing glaucoma goes up considerably with aging". As the natives of the United States ages, the number of glaucoma cases will logically increase. As Olivier said, "We're just going to have more people who are older and living longer, so we'll have more glaucoma".
Tuesday 19 November 2013
Five Years Later, Cured Depression Will Return In Adolescents
Five Years Later, Cured Depression Will Return In Adolescents.
Although almost all teens who were treated for biggest gloom initially recovered, about half ended up torture a relapse within five years, a new study found. And those recurrences were more likely to confirm girls than boys, the researchers found. "We've known for a long time that people are prevalent to revert back to depression - that 50 percent would relapse even though they had recovered. I don't believe that surprised many people," said Keith Young, vice chair for research in the department of psychiatry and behavioral knowledge at Texas A&M Health Science Center College of Medicine.
Young was not labyrinthine with the study. Study lead author John Curry, a professor of psychiatry and behavioral sciences at Duke University, said the findings nitty-gritty up the "need to develop treatments that will prevent recurrence of two depression". Although some of those treatments may be coming down the pipeline, Young emphasized that the new sanctum provides a clue as to what clinicians could be doing better.
And "People on short-term treatment programs that didn't surely follow through didn't do as well in the long run. Big studies like this give clinicians justification for really pushing subjects to stay in the programs," said Young. "It's like when you're taking an antibiotic, you have to quarter it all even if you start feeling better. The idea is to treat adolescent depression aggressively until all symptoms are gone and the being is better".
The findings are published in the Nov 1, 2010 issue of Archives of General Psychiatry. According to obscurity information in the article, almost 6 percent of adolescent girls and 4Ð ±6 percent of boys fall off from major depressive disorder. Although studies have looked at the short-term outcomes of remedying (which tend to be good), less is known about what happens over the longer term, the think over authors stated.
Although almost all teens who were treated for biggest gloom initially recovered, about half ended up torture a relapse within five years, a new study found. And those recurrences were more likely to confirm girls than boys, the researchers found. "We've known for a long time that people are prevalent to revert back to depression - that 50 percent would relapse even though they had recovered. I don't believe that surprised many people," said Keith Young, vice chair for research in the department of psychiatry and behavioral knowledge at Texas A&M Health Science Center College of Medicine.
Young was not labyrinthine with the study. Study lead author John Curry, a professor of psychiatry and behavioral sciences at Duke University, said the findings nitty-gritty up the "need to develop treatments that will prevent recurrence of two depression". Although some of those treatments may be coming down the pipeline, Young emphasized that the new sanctum provides a clue as to what clinicians could be doing better.
And "People on short-term treatment programs that didn't surely follow through didn't do as well in the long run. Big studies like this give clinicians justification for really pushing subjects to stay in the programs," said Young. "It's like when you're taking an antibiotic, you have to quarter it all even if you start feeling better. The idea is to treat adolescent depression aggressively until all symptoms are gone and the being is better".
The findings are published in the Nov 1, 2010 issue of Archives of General Psychiatry. According to obscurity information in the article, almost 6 percent of adolescent girls and 4Ð ±6 percent of boys fall off from major depressive disorder. Although studies have looked at the short-term outcomes of remedying (which tend to be good), less is known about what happens over the longer term, the think over authors stated.
Sunday 17 November 2013
An Approved Vaccine To Treat Prostate Cancer Has Few Side Effects
An Approved Vaccine To Treat Prostate Cancer Has Few Side Effects.
The newly approved health-giving prostate cancer vaccine, Provenge, is tried and true and has few sect effects, a new study finds. In April, the US Food and Drug Administration approved the vaccine for use in men with advanced prostate cancer who had failed hormone therapy. "Provenge was approved based on both aegis and clinical data," said steer researcher Dr Simon J Hall, armchair of urology at Mount Sinai Medical Center in New York City.
This safeness data shows that there are very limited side effects, Hall added. The usefulness of the vaccine for patients with metastatic hormone-resistant prostate cancer is that it has fewer ancillary effects than chemotherapy, which is the only other treatment option for these patients, Hall explained. In addition, Provenge has improved survival over chemotherapy, he added.
The common survival time for men given Provenge is 4,5 months, although some patients adage their lives extended by two to three years. "This is a newly handy treatment, with very limited side effects, compared to anything else that a man would be making allowance for in this state," Hall said. Hall was to present the results on Monday at the American Urological Association annual converging in San Francisco.
Data from four phase 3 trials, which included 904 men randomized to either Provenge or placebo, showed the vaccine extended survival, improved prominence of sentience and had only mild side effects. In fact, more than 83 percent of the men who received Provenge were able to do play activities without any restrictions, the researchers noted.
The newly approved health-giving prostate cancer vaccine, Provenge, is tried and true and has few sect effects, a new study finds. In April, the US Food and Drug Administration approved the vaccine for use in men with advanced prostate cancer who had failed hormone therapy. "Provenge was approved based on both aegis and clinical data," said steer researcher Dr Simon J Hall, armchair of urology at Mount Sinai Medical Center in New York City.
This safeness data shows that there are very limited side effects, Hall added. The usefulness of the vaccine for patients with metastatic hormone-resistant prostate cancer is that it has fewer ancillary effects than chemotherapy, which is the only other treatment option for these patients, Hall explained. In addition, Provenge has improved survival over chemotherapy, he added.
The common survival time for men given Provenge is 4,5 months, although some patients adage their lives extended by two to three years. "This is a newly handy treatment, with very limited side effects, compared to anything else that a man would be making allowance for in this state," Hall said. Hall was to present the results on Monday at the American Urological Association annual converging in San Francisco.
Data from four phase 3 trials, which included 904 men randomized to either Provenge or placebo, showed the vaccine extended survival, improved prominence of sentience and had only mild side effects. In fact, more than 83 percent of the men who received Provenge were able to do play activities without any restrictions, the researchers noted.
Stem Cells From A New Source For The Treatment Of The Heart
Stem Cells From A New Source For The Treatment Of The Heart.
Stem cells from the amniotic sac that surrounds a fetus may someday be utilized to vamp injure caused by a heart attack, Japanese researchers report. The work, so far only conducted in animals, raises the plausibility of a non-controversial source of stem cells to upon not only heart disease but also many other conditions, said Dr Shunichiro Miyoshi, an assistant professor in the cardiology unit at the Keio University School of Medicine, and co-author of a report in the May 28 online emerge of Circulation Research. "I believe these cells may be utilized in the treatment of autoimmune diseases such as SLA systemic lupus erythematosus and rheumatoid arthritis," Miyoshi said.
The amniotic sac is typically discarded after childbirth. SLA is an autoimmune disability in which the body's untouched system cells mistakenly strike healthy tissue. The cells that Miyoshi and his colleagues have used in mouse studies can simply be obtained in large numbers and offer another major advantage: they bypass the call to match donor-recipient cell typing, Miyoshi explained.
So "At the present time there is no obstacle for clinical utilization," he said. "We can obtain amniotic membrane from every delivery. We do not shortage to match donor-recipient matching of complicated HLA typing". HLA refers to the protein markers that are found on most of the body's cells. Transplanted cells that argue from the recipient's HLA type will be attacked and destroyed by the invulnerable system.
The Keio researchers have begun a series of studies aimed at the human use of the amniotic halt cells. "Now we are performing the experiment on a swine model," Miyoshi said. "Immediately after we get a marvellous result, we are planning to perform clinical trials. I believe it will go on within a few years. But it may depend on the strength of our government regulation".
The journal report describes laboratory work in which diminish cells obtained from amniotic membranes were transformed into heart cells, 33 percent of which trounce spontaneously and which improved rat heart function by more than 34 percent when injected two weeks after a soul attack. The injected cells decreased the area of heart damage by 13 percent to 18 percent and survived for more than four weeks in the rats without the use of drugs to free-for-all protected rejection. The amniotic cells are much easier to convert into heart cells than stem cells from other sources, such as bone marrow or fat, Miyoshi said.
Stem cells from the amniotic sac that surrounds a fetus may someday be utilized to vamp injure caused by a heart attack, Japanese researchers report. The work, so far only conducted in animals, raises the plausibility of a non-controversial source of stem cells to upon not only heart disease but also many other conditions, said Dr Shunichiro Miyoshi, an assistant professor in the cardiology unit at the Keio University School of Medicine, and co-author of a report in the May 28 online emerge of Circulation Research. "I believe these cells may be utilized in the treatment of autoimmune diseases such as SLA systemic lupus erythematosus and rheumatoid arthritis," Miyoshi said.
The amniotic sac is typically discarded after childbirth. SLA is an autoimmune disability in which the body's untouched system cells mistakenly strike healthy tissue. The cells that Miyoshi and his colleagues have used in mouse studies can simply be obtained in large numbers and offer another major advantage: they bypass the call to match donor-recipient cell typing, Miyoshi explained.
So "At the present time there is no obstacle for clinical utilization," he said. "We can obtain amniotic membrane from every delivery. We do not shortage to match donor-recipient matching of complicated HLA typing". HLA refers to the protein markers that are found on most of the body's cells. Transplanted cells that argue from the recipient's HLA type will be attacked and destroyed by the invulnerable system.
The Keio researchers have begun a series of studies aimed at the human use of the amniotic halt cells. "Now we are performing the experiment on a swine model," Miyoshi said. "Immediately after we get a marvellous result, we are planning to perform clinical trials. I believe it will go on within a few years. But it may depend on the strength of our government regulation".
The journal report describes laboratory work in which diminish cells obtained from amniotic membranes were transformed into heart cells, 33 percent of which trounce spontaneously and which improved rat heart function by more than 34 percent when injected two weeks after a soul attack. The injected cells decreased the area of heart damage by 13 percent to 18 percent and survived for more than four weeks in the rats without the use of drugs to free-for-all protected rejection. The amniotic cells are much easier to convert into heart cells than stem cells from other sources, such as bone marrow or fat, Miyoshi said.
Saturday 16 November 2013
Deer Ticks Carry Lyme Disease Germs
Deer Ticks Carry Lyme Disease Germs.
People who go outdoors in several regions of the United States may have something else to responsibility about. Scientists dispatch that there's another troublesome basis hiding in the deer tick that already harbors the Lyme disease bacterium. There are indications that the seed infects a few thousand Americans a year, potentially causing flu-like symptoms such as fever. In one newly reported case, a girl with existing medical problems appeared to have brain tumour and dementia caused by an infection.
It is not clear, however, how serious of a threat may be posed by the germ. For the moment, Lyme affliction appears to be much more prevalent. And four other germs that affect humans hide in deer ticks. Still, scientists say the germ is cause for concern.
And "This would not be commonly picked up by any of the accepted tests for Lyme disease," said Victor Berardi, co-author of one of two reports about the bug in the Jan 17, 2013 issue of the New England Journal of Medicine. The bacterium in problem is Borrelia miyamotoi and is found on deer ticks (also known as blacklegged ticks) in parts of the state where Lyme disease is prevalent.
In 2011, Russian researchers reported that individuals there were infected by the bacterium, and the new reports have found that it has infected people in the United States as well. "We've known about this bacterium for a large time - at least 10 years," said Sam Telford III, a professor of catching disease at Tufts University in Medford, Mass, who co-authored the disclose with Berardi.
People who go outdoors in several regions of the United States may have something else to responsibility about. Scientists dispatch that there's another troublesome basis hiding in the deer tick that already harbors the Lyme disease bacterium. There are indications that the seed infects a few thousand Americans a year, potentially causing flu-like symptoms such as fever. In one newly reported case, a girl with existing medical problems appeared to have brain tumour and dementia caused by an infection.
It is not clear, however, how serious of a threat may be posed by the germ. For the moment, Lyme affliction appears to be much more prevalent. And four other germs that affect humans hide in deer ticks. Still, scientists say the germ is cause for concern.
And "This would not be commonly picked up by any of the accepted tests for Lyme disease," said Victor Berardi, co-author of one of two reports about the bug in the Jan 17, 2013 issue of the New England Journal of Medicine. The bacterium in problem is Borrelia miyamotoi and is found on deer ticks (also known as blacklegged ticks) in parts of the state where Lyme disease is prevalent.
In 2011, Russian researchers reported that individuals there were infected by the bacterium, and the new reports have found that it has infected people in the United States as well. "We've known about this bacterium for a large time - at least 10 years," said Sam Telford III, a professor of catching disease at Tufts University in Medford, Mass, who co-authored the disclose with Berardi.
Thursday 14 November 2013
Most Americans And Canadians With HIV Diagnosed Too Late.
Americans and Canadians infected with HIV are not getting diagnosed post-haste enough after exposure, resulting in a potentially dangerous hold off in lifesaving treatment, a new large study suggests. The observation stems from an investigation involving nearly 45000 HIV-positive patients in both countries, which focused on a key yardstick for invulnerable system strength - CD4 cell counts - at the time each patient firstly began treatment. CD4 counts measure the number of "helper" T-cells that are HIV's preferred target.
Reviewing the participants' medical records between 1997 and 2007, the yoke found that throughout the 10-year study period, the usual CD4 count at the time of first treatment was below the recommended level that scientists have yearn identified as the ideal starting point for medical care. "The public health implications of our findings are clear," analyse author Dr Richard Moore, from the Johns Hopkins University School of Medicine in Baltimore, said in a despatch release. "Delayed diagnosis reduces survival, and individuals enter into HIV attention with lower CD4 counts than the guidelines for initiating antiretroviral therapy". A poke in getting treatment not only increases the chance that the disease will progress, but boosts the risk of transmission, he added.
Americans and Canadians infected with HIV are not getting diagnosed post-haste enough after exposure, resulting in a potentially dangerous hold off in lifesaving treatment, a new large study suggests. The observation stems from an investigation involving nearly 45000 HIV-positive patients in both countries, which focused on a key yardstick for invulnerable system strength - CD4 cell counts - at the time each patient firstly began treatment. CD4 counts measure the number of "helper" T-cells that are HIV's preferred target.
Reviewing the participants' medical records between 1997 and 2007, the yoke found that throughout the 10-year study period, the usual CD4 count at the time of first treatment was below the recommended level that scientists have yearn identified as the ideal starting point for medical care. "The public health implications of our findings are clear," analyse author Dr Richard Moore, from the Johns Hopkins University School of Medicine in Baltimore, said in a despatch release. "Delayed diagnosis reduces survival, and individuals enter into HIV attention with lower CD4 counts than the guidelines for initiating antiretroviral therapy". A poke in getting treatment not only increases the chance that the disease will progress, but boosts the risk of transmission, he added.
Monday 11 November 2013
Special Care For Elderly Pets
Special Care For Elderly Pets.
Old period seems to prowl up on pets just as it does in people. Long before you expect it, Fido and Snowball are no longer able to bolt out the door or romp onto the bed. But with routine visits to the vet, regular exercise and good load control, you can help your beloved pet ward off the onset of age-related disease, one veterinary pundit suggests. "Aging pets are a lot like aging people with respect to diseases," Susan Nelson, a Kansas State University subsidiary professor of clinical services, said in a university bulletin release.
Diabetes, chronic kidney disease, cancer, osteoarthritis, periodontal disease and heart infection are among the problems pets face as they grow older, she noted. "Like people, assigned exams and tests can help detect some of these problems earlier and make treatment more successful," Nelson added, making a significant reference to heartworm prevention and general vaccinations. "It's also impressive to work closely with your veterinarian," Nelson said, because "many pets are on more than one type of medication as they age, just match humans".
Cats between 8 and 11 years (equal to 48 to 60 in human years) are considered "senior," while those over the mature of 12 fall into the category of "geriatric," Nelson explained. For dogs it depends on weight: those under 20 pounds are considered chief at 8 years, and geriatric at 11 years. Those 120 pounds and up, however, are considered ranking at 4 years and geriatric at 6 years, with a sliding age-scale applied to canines between 20 and 120 pounds.
Old period seems to prowl up on pets just as it does in people. Long before you expect it, Fido and Snowball are no longer able to bolt out the door or romp onto the bed. But with routine visits to the vet, regular exercise and good load control, you can help your beloved pet ward off the onset of age-related disease, one veterinary pundit suggests. "Aging pets are a lot like aging people with respect to diseases," Susan Nelson, a Kansas State University subsidiary professor of clinical services, said in a university bulletin release.
Diabetes, chronic kidney disease, cancer, osteoarthritis, periodontal disease and heart infection are among the problems pets face as they grow older, she noted. "Like people, assigned exams and tests can help detect some of these problems earlier and make treatment more successful," Nelson added, making a significant reference to heartworm prevention and general vaccinations. "It's also impressive to work closely with your veterinarian," Nelson said, because "many pets are on more than one type of medication as they age, just match humans".
Cats between 8 and 11 years (equal to 48 to 60 in human years) are considered "senior," while those over the mature of 12 fall into the category of "geriatric," Nelson explained. For dogs it depends on weight: those under 20 pounds are considered chief at 8 years, and geriatric at 11 years. Those 120 pounds and up, however, are considered ranking at 4 years and geriatric at 6 years, with a sliding age-scale applied to canines between 20 and 120 pounds.
Sunday 10 November 2013
The Mortality Rate For People With Type 1 Diabetes Is Reduced
The Mortality Rate For People With Type 1 Diabetes Is Reduced.
Death rates have dropped significantly in public with specimen 1 diabetes, according to a late study. Researchers also found that kinsmen diagnosed in the late 1970s have an even downgrade mortality rate compared with those diagnosed in the 1960s. "The encouraging fetish is that, given good diabetes control, you can have a near-normal verve expectancy," said the study's senior author, Dr Trevor J Orchard, a professor of epidemiology, c physic and pediatrics in the Graduate School of Public Health at the University of Pittsburgh, Penn. But, the analyse also found that mortality rates for consumers with model 1 still remain significantly higher than for the general population - seven times higher, in fact accutane. And some groups, such as women, take up to have disproportionately higher mortality rates: women with typeface 1 diabetes are 13 times more plausible to die than are their female counterparts without the disease.
Results of the scrutiny are published in the December proclamation of Diabetes Care. Type 1 diabetes is an autoimmune bug that causes the body's immune system to mistakenly attack the body's insulin-producing cells. As a result, proletariat with quintessence 1 diabetes make little or no insulin, and must rely on lifelong insulin replacement either through injections or pint-sized catheter attached to an insulin pump.
Insulin is a hormone that allows the body to use blood sugar. Insulin replacement psychoanalysis isn't as remarkable as naturally-produced insulin, however. People with order 1 diabetes often have blood sugar levels that are too squiffy or too low, because it's difficult to predict in all respects how much insulin you'll need.
When blood sugar levels are too tall due to too little insulin, it causes damage that can lead to long period complications, such as an increased risk of kidney failure and pluck disease. On the other hand, if you have too much insulin, blood sugar levels can descent dangerously low, potentially leading to coma or death.
These factors are why paradigm 1 diabetes has long been associated with a significantly increased hazard of death, and a shortened life expectancy. However, numerous improvements have been made in category 1 diabetes directorate during the past 30 years, including the advent of blood glucose monitors, insulin pumps, newer insulins, better medications to retard complications and most recently ceaseless glucose monitors.
Death rates have dropped significantly in public with specimen 1 diabetes, according to a late study. Researchers also found that kinsmen diagnosed in the late 1970s have an even downgrade mortality rate compared with those diagnosed in the 1960s. "The encouraging fetish is that, given good diabetes control, you can have a near-normal verve expectancy," said the study's senior author, Dr Trevor J Orchard, a professor of epidemiology, c physic and pediatrics in the Graduate School of Public Health at the University of Pittsburgh, Penn. But, the analyse also found that mortality rates for consumers with model 1 still remain significantly higher than for the general population - seven times higher, in fact accutane. And some groups, such as women, take up to have disproportionately higher mortality rates: women with typeface 1 diabetes are 13 times more plausible to die than are their female counterparts without the disease.
Results of the scrutiny are published in the December proclamation of Diabetes Care. Type 1 diabetes is an autoimmune bug that causes the body's immune system to mistakenly attack the body's insulin-producing cells. As a result, proletariat with quintessence 1 diabetes make little or no insulin, and must rely on lifelong insulin replacement either through injections or pint-sized catheter attached to an insulin pump.
Insulin is a hormone that allows the body to use blood sugar. Insulin replacement psychoanalysis isn't as remarkable as naturally-produced insulin, however. People with order 1 diabetes often have blood sugar levels that are too squiffy or too low, because it's difficult to predict in all respects how much insulin you'll need.
When blood sugar levels are too tall due to too little insulin, it causes damage that can lead to long period complications, such as an increased risk of kidney failure and pluck disease. On the other hand, if you have too much insulin, blood sugar levels can descent dangerously low, potentially leading to coma or death.
These factors are why paradigm 1 diabetes has long been associated with a significantly increased hazard of death, and a shortened life expectancy. However, numerous improvements have been made in category 1 diabetes directorate during the past 30 years, including the advent of blood glucose monitors, insulin pumps, newer insulins, better medications to retard complications and most recently ceaseless glucose monitors.
Sunday 3 November 2013
Flu Vaccines Approved For Next Winter, Will Protect Against Three Strains Of Influenza, Including H1N1
Flu Vaccines Approved For Next Winter, Will Protect Against Three Strains Of Influenza, Including H1N1.
The flu vaccines approved for the 2010-11 age screen against three strains of influenza, including the 2009 H1N1 pandemic swine flu strain, the United States Food and Drug Administration has announced tablet. Because the 2009 H1N1 virus emerged after opus had started on carry on year's seasonal flu vaccine, two type vaccines were needed rearmost ripen to care for against seasonal flu and the 2009 H1N1 virus.
This year, rank and file will be missing only one vaccine, the FDA said. Each year, experts from the World Health Organization, the FDA, the US Centers for Disease Control and Prevention and other institutions analyze flu virus samples and patterns controlled worldwide in sect to condition which strains are most expected to cause disease during the upcoming season.
The vaccines for the 2010-11 flu occasion contain the following strains:
* A/California/7/09 (H1N1)-like virus (pandemic (H1N1) 2009 influenza virus),
The flu vaccines approved for the 2010-11 age screen against three strains of influenza, including the 2009 H1N1 pandemic swine flu strain, the United States Food and Drug Administration has announced tablet. Because the 2009 H1N1 virus emerged after opus had started on carry on year's seasonal flu vaccine, two type vaccines were needed rearmost ripen to care for against seasonal flu and the 2009 H1N1 virus.
This year, rank and file will be missing only one vaccine, the FDA said. Each year, experts from the World Health Organization, the FDA, the US Centers for Disease Control and Prevention and other institutions analyze flu virus samples and patterns controlled worldwide in sect to condition which strains are most expected to cause disease during the upcoming season.
The vaccines for the 2010-11 flu occasion contain the following strains:
* A/California/7/09 (H1N1)-like virus (pandemic (H1N1) 2009 influenza virus),
Saturday 2 November 2013
Nickel Allergy From A Cell Phone
Nickel Allergy From A Cell Phone.
If you're an incessant cubicle phone owner and a perplexing rash appears along your jaw, cheek or ear, chances are you're allergic to nickel, a metal commonly Euphemistic pre-owned in stall phones. While allergists have long been familiar with nickel allergy, "cell phone rash" is just starting to show up on their radar screen, said Dr Luz Fonacier, first place of allergy and immunology at Winthrop University Hospital in Mineola, NY vivioptal capsules. "Increased use of chamber phones with immense use plans has led to prolonged endangerment to the nickel in phones," said Fonacier, who is scheduled to talk over the condition in a larger presentation on skin allergies Nov 14, 2010 at the American College of Allergy, Asthma and Immunology annual intersection in Phoenix.
Symptoms of apartment phone allergy incorporate a red, bumpy, itchy rash in areas where the nickel-containing parts of a room phone touch the face. It can even fake fingertips of those who text continuously on buttons containing nickel. In unembellished cases, blisters and itchy sores can develop.
Fonacier said she sees many patients who are allergic to nickel and don't be versed it. "They come in with no recommendation of what is causing their allergic reaction," said Fonacier, also a professor of clinical cure-all at the State University of New York at Stony Brook. Sometimes, she traces her patients' symptoms to their cell phones.
In 2000, a researcher in Italy documented the elementary suitcase of cell phone rash, prompting other inspect on the condition. In a 2008 look at published in the Canadian Medical Association Journal, US researchers tested for nickel in 22 handsets from eight manufacturers; 10 contained the metal. The parts with the most nickel were the menu buttons, decorative logos on the headsets and the metal frames around the melted crystal spectacle (LCD) screens.
Cell phone impetuous is still not well known, said allergist Dr Stanley M Fineman, a clinical comrade professor at the Emory University School of Medicine in Atlanta. While he's treated more cases of nickel allergy caused by piercings than by cell phones, "it's decorous for allergists and dermatologists to have cell phone write to dermatitis on their radar screens," he said.
If you're an incessant cubicle phone owner and a perplexing rash appears along your jaw, cheek or ear, chances are you're allergic to nickel, a metal commonly Euphemistic pre-owned in stall phones. While allergists have long been familiar with nickel allergy, "cell phone rash" is just starting to show up on their radar screen, said Dr Luz Fonacier, first place of allergy and immunology at Winthrop University Hospital in Mineola, NY vivioptal capsules. "Increased use of chamber phones with immense use plans has led to prolonged endangerment to the nickel in phones," said Fonacier, who is scheduled to talk over the condition in a larger presentation on skin allergies Nov 14, 2010 at the American College of Allergy, Asthma and Immunology annual intersection in Phoenix.
Symptoms of apartment phone allergy incorporate a red, bumpy, itchy rash in areas where the nickel-containing parts of a room phone touch the face. It can even fake fingertips of those who text continuously on buttons containing nickel. In unembellished cases, blisters and itchy sores can develop.
Fonacier said she sees many patients who are allergic to nickel and don't be versed it. "They come in with no recommendation of what is causing their allergic reaction," said Fonacier, also a professor of clinical cure-all at the State University of New York at Stony Brook. Sometimes, she traces her patients' symptoms to their cell phones.
In 2000, a researcher in Italy documented the elementary suitcase of cell phone rash, prompting other inspect on the condition. In a 2008 look at published in the Canadian Medical Association Journal, US researchers tested for nickel in 22 handsets from eight manufacturers; 10 contained the metal. The parts with the most nickel were the menu buttons, decorative logos on the headsets and the metal frames around the melted crystal spectacle (LCD) screens.
Cell phone impetuous is still not well known, said allergist Dr Stanley M Fineman, a clinical comrade professor at the Emory University School of Medicine in Atlanta. While he's treated more cases of nickel allergy caused by piercings than by cell phones, "it's decorous for allergists and dermatologists to have cell phone write to dermatitis on their radar screens," he said.
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