New Methods Of Treatment Of Intestinal Infections

New Methods Of Treatment Of Intestinal Infections.
Here's a unique construction on the old idea of not letting anything go to waste. According to a small new Dutch study, considerate stool - which contains billions of useful bacteria - can be donated from one human to another to cure a severe, common and recurrent bacterial infection. People who have the infection, called Clostridium difficile (or C difficile), observation long bouts of severe diarrhea, abdominal pain, nausea and vomiting. For many, antibiotics are ineffective.

To press matters worse, prepossessing antibiotics for months and months wipes out a large percentage of bacteria that would normally be accommodating in fighting the infection. "Clostridium difficile only grows when normal bacteria are absent," explained investigate author Dr Josbert Keller, a gastroenterologist at Hagaziekenhuis Hospital, in The Hague. The stool from a donor, conflicting with a salt solution called saline, can be instilled into the crazy person's intestinal system, almost like parachuting a team of commandos into enemy territory.

The vigorous person's abundant and diverse gut bacteria go to work within days, wiping out the stubborn C difficile that the antibiotics have failed to kill, according to the study. "Everybody makes jokes about this, but for the patients it very makes a big difference," Keller said. "People are desperate".

The research, published Jan 16, 2013 in the New England Journal of Medicine, showed that the infusion of benefactor stool was significantly more serviceable in treating iterative C difficile infection than was vancomycin, an antibiotic. Of the 16 boning up participants, 13 (81 percent) of the patients had resolution of their infection after just one infusion of stool and two others were cured with a support treatment. The approach is not new, but this research is the first controlled whack ever done, according to Dr Ciaran Kelly, a professor of medicine at Harvard Medical School and the designer of an editorial accompanying the research.

Previous reports have been simple case studies, which are considered less conclusive. C difficile is the most commonly identified cause of hospital-acquired communicable diarrhea in the United States, according to Kelly. The take care of of giving and receiving a stool donation is relatively simple. Study author Keller said participants typically asked lineage members to donate part of a bowel movement, thoughtful it would be more comfortable to receive such a donation of such a substance from someone they knew.