How Exercise Helps Prevent Heart Disease And Other Diseases

How Exercise Helps Prevent Heart Disease And Other Diseases.
A supplementary work provides tantalizing clues about how exercise helps ward off heartlessness disease and other ills: Fit people have more fat-burning molecules in their blood than less fit people after exercise. And the very fittest are even more efficient, on a biochemical level, at generating fat-burning molecules that interpose down and light up fats and sugars, the study reports. A better understanding of these fat-burning molecules, called metabolites, may not only aid athletic performance, but help prevent or treat chronic illnesses such as type 2 diabetes and pump disease by correcting metabolite deficiencies, the researchers said.

The study, outwardly the first of its kind, takes a look at how regular exercise - that is, fitness - alters metabolism lawful down to the level of chemical changes in the blood. "Every metabolic action in the body results in the product of fat-burning metabolites," said senior study author Dr Robert Gerszten, principal of clinical and translational research at Massachusetts General Hospital Heart Center. "A blood trial contains hundreds of these metabolites and can provide a snapshot of any individual's form status".

Previous studies had investigated changes in metabolites generated by exercise, but researchers were limited to viewing a few molecules at a moment in hospital laboratories. But in the new study, a technique developed by the MGH Heart Center in collaboration with MIT and Harvard allowed researchers to spy the full spectrum of the fat-burning molecules in action. They in use mass spectrometry - which can analyze blood samples in tiniest detail - to develop a "chemical snapshot" of the metabolic effects of exercise.

To tail the fat-burning molecules, the researchers took blood samples from healthy participants before, just following, and after an exert stress test that was about 10 minutes long. Then they measured the blood levels of 200 diverse metabolites, which are released into the blood in tiny quantities. Exercise resulted in changes to levels of more than 20 metabolites that were convoluted with the metabolism of sugar, fats, amino acids, along with the use of ATP, the underlying source of cellular energy, according to the study.