Morphine Can Protect The Brains Of People Suffering From HIV Infection

Morphine Can Protect The Brains Of People Suffering From HIV Infection.
The palliative morphine may helper protect against HIV-associated dementia, says a untrained study tablets. Georgetown University Medical Center researchers found that morphine protected rat neurons from HIV toxicity, a detection that could lead to the development of new drugs to treat individuals with HIV-related dementia, which causes depression, anxiety and physical and mental problems.

So "We find credible that morphine may be neuroprotective in a subset of people infected with HIV," lead investigator Italo Mocchetti, a professor of neuroscience, said in a Georgetown rumour release. He and his colleagues conducted the work because they knew that some people with HIV who are heroin users never develop HIV brain dementia proextenderworld.com. Morphine is nearly the same to heroin.

In their tests on rats, the researchers found that morphine triggers brain cells called astrocytes to in a protein called CCL5, which activates factors that suppress HIV infection in unaffected cells. CCL5 "is known to be important in blood, but we didn't know it is secreted in the brain. Our premiss is that it is in the brain to prevent neurons from dying".

The study was to be presented at the annual session of the Society of NeuroImmune Pharmacology, April 13 to 17 in Manhattan Beach, Calif. "Ideally, we can use this low-down to develop a morphine-like compound that does not have the typical dependency and tolerance issues that morphine has".

Austrian Scientists Have Determined The Effect Of Morphine On Blood Coagulation

Austrian Scientists Have Determined The Effect Of Morphine On Blood Coagulation.
Morphine appears to limit the effectiveness of the commonly second-hand blood-thinning remedy Plavix, which could hamper emergency-room efforts to treat heart attack victims, Austrian researchers report. The decision could create serious dilemmas in the ER, where doctors have to weigh a affection patient's intense pain against the need to break up and prevent blood clots, said Dr Deepak Bhatt, management director of interventional cardiovascular programs at Brigham and Women's Hospital Heart and Vascular Center, in Boston. "If a indefatigable is having crushing heart pain, you can't just notify them to tough it out, and morphine is the most commonly used medication in that situation," said Bhatt, who was not twisted in the study.

And "Giving them morphine is the humane thing to do, but it could also create delays in care". Doctors will have to be surprisingly careful if a heart attack patient needs to have a stent implanted. Blood thinners are vital in preventing blood clots from forming around the stent. "If that case is unfolding, it requires a little bit of extra thought on the part of the physician whether they want to give that full slug of morphine or not".

About half of the 600000 stent procedures that operate place in the United States each year turn up as the result of a heart attack, angina or other acute coronary syndrome. The Austrian researchers focused on 24 nourishing people who received either a dose of Plavix with an injection of morphine or a placebo drug. Morphine delayed the knack of Plavix (clopidogrel) to thin a patient's blood by an usual of two hours, the researchers said.