Implantable Heart Defibrillator Prolongs Life Expectancy.
Implantable hub defibrillators aimed at preventing abrupt cardiac death are as effective at ensuring patient survival during real-world use as they have proven to be in studies, researchers report. The novel finding goes some way toward addressing concerns that the carefully monitored vigilance offered to patients participating in well-run defibrillator investigations may have oversold their reciprocal benefits by failing to account for how they might perform in the real-world natural. The study is published in the Jan 2, 2013 emanate of the Journal of the American Medical Association.
So "Many people dispute how the results of clinical trials apply to patients in routine practice," lead author Dr Sana Al-Khatib, an electrophysiologist and colleague of the Duke Clinical Research Institute in Durham, NC, acknowledged in a dossier news release lingam valippam vekkan sex malayalm. "But we showed that patients in real-world practice who receive a defibrillator, but who are most probably not monitored at the same level provided in clinical trials, have similar survival outcomes compared to patients who received a defibrillator in the clinical trials".
Showing posts with label trials. Show all posts
Showing posts with label trials. Show all posts
Tuesday 19 June 2018
Sunday 21 August 2016
Doctors Do A Blood Transfusion For The Involvement Of Patients In Trials Of New Cancer Drugs
Doctors Do A Blood Transfusion For The Involvement Of Patients In Trials Of New Cancer Drugs.
Canadian researchers aver they've noticed a distressing trend: Cancer doctors ordering supererogatory blood transfusions so that critically ill patients can qualify for drug trials. In a letter published recently in the New England Journal of Medicine, the researchers article on three cases during the last year in Toronto hospitals in which physicians ordered blood transfusions that could fetch the patients appear healthier for the solitary purpose of getting them into clinical trials for chemotherapy drugs. The practice raises both medical and virtuous concerns, the authors say.
And "On the physician side, you want to do the best for your patients," said co-author Dr Jeannie Callum, top dog of transfusion medicine and tissue banks at Sunnybrook Health Sciences Centre in Toronto. "If these patients have no other options hand to them, you want to do everything you can to get them into a clinical trial. But the submissive is put in a horrible position, which is, 'If you want in to the trial, you have to have the transfusion.' But the transfusion only carries risks to them".
A surprisingly serious complication of blood transfusions is transfusion-related pointed lung injury, which occurs in about one in 5000 transfusions and usually requires the patient to go on life support, said Callum. But in addition to the potential for physical harm, enrolling very sick persons in a clinical trial can also skew the study's results - making the drug perform worse than it might in patients whose sickness was not as far along.
The unnecessary transfusions were discovered by the Toronto Transfusion Collaboration, a consortium of six urban area hospitals formed to carefully review all transfusions as a means of improving patient safety. At this point, it's inconceivable to know how often transfusions are ordered just to get patients into clinical trials. When she contacted colleagues around the period to find out if the practice is widespread, all replied that they didn't sift the reasons for ordering blood transfusions and so would have no way of knowing.
Canadian researchers aver they've noticed a distressing trend: Cancer doctors ordering supererogatory blood transfusions so that critically ill patients can qualify for drug trials. In a letter published recently in the New England Journal of Medicine, the researchers article on three cases during the last year in Toronto hospitals in which physicians ordered blood transfusions that could fetch the patients appear healthier for the solitary purpose of getting them into clinical trials for chemotherapy drugs. The practice raises both medical and virtuous concerns, the authors say.
And "On the physician side, you want to do the best for your patients," said co-author Dr Jeannie Callum, top dog of transfusion medicine and tissue banks at Sunnybrook Health Sciences Centre in Toronto. "If these patients have no other options hand to them, you want to do everything you can to get them into a clinical trial. But the submissive is put in a horrible position, which is, 'If you want in to the trial, you have to have the transfusion.' But the transfusion only carries risks to them".
A surprisingly serious complication of blood transfusions is transfusion-related pointed lung injury, which occurs in about one in 5000 transfusions and usually requires the patient to go on life support, said Callum. But in addition to the potential for physical harm, enrolling very sick persons in a clinical trial can also skew the study's results - making the drug perform worse than it might in patients whose sickness was not as far along.
The unnecessary transfusions were discovered by the Toronto Transfusion Collaboration, a consortium of six urban area hospitals formed to carefully review all transfusions as a means of improving patient safety. At this point, it's inconceivable to know how often transfusions are ordered just to get patients into clinical trials. When she contacted colleagues around the period to find out if the practice is widespread, all replied that they didn't sift the reasons for ordering blood transfusions and so would have no way of knowing.
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